|
Biomedical
Laboratory
The biomedical laboratory at Utah State University
has a long history of immunogenetic research in
autism. The laboratory has been on the leading
edge of immune function mechanisms in autism for
about 15 years. Numerous scientific papers have
been published describing the association and
linkage of Human Leukocyte Antigen (HLA) alleles
on chromosome 6 with autism. Our recent research
strongly indicates that certain combination of
HLA alleles (haplotypes) is common in autism.
This work is developing rapidly due to collaboration
with scientists who have access to thousands of
newborn blood spots from autistic subjects and
controls that we are using for genotyping/haplotyping.
Lead Researchers:
Anthony
R. Torres, M.D.
(Director) |
|
Medical
Degree—University of Utah
Residency in Laboratory Medicine at Yale University
Research Associate at National Institutes
of Health |
| Dennis
Odell, M.D. |
|
Medical
Degree—University of Chicago
Residency in Pediatrics at Stanford University |
| Thayne
Sweeten, Ph.D. |
|
Doctorate
in Medical Neurobiology at Indiana University |
| Adele
Cutler, Ph.D. |
|
Doctorate
in Mathematics, University of California,
Berkeley |
Recent Autism Publications:
Confirmation of the association of the C4B null
allele in autism.
Human Immunology.
2005 February; 66(2):140-5.
Is
fever suppression involved in the etiology of
autism and neurodevelopmental disorders. BMC
Pediatrics. 2005 September 2; 3(1):9. (electronic
publication)
Decreased
Expression of CD95(FAS/APO-1) on CD4+ T-lymphocytes
from Subjects with Autism. Journal
of Developmental and Physical Disabilities. 2003;
15(2), 155-163.
The
Transmission disequilibrium Test Suggests that
HLA-DR4 and DR13 are linked to Autism Spectrum
Disorder. Human
Immunology, 2002; 63, 311-316.
The
Association of MHC genes with Autism. Frontiers
in Bioscience., 2001; 6, d936-943.
Chief Collaborators:
| Dr.
Judith Grether |
|
California
Department of Health Services |
| Dr.
Lisa Croen |
|
Kaiser
Permanente, Inc. California |
| Dr.
David Ward |
|
Nevada
Cancer Institute, Las Vegas, Nevada |
| Dr.
Robert Yolken |
|
John
Hopkins University, Baltimore, Maryland |
| Dr.
Susan E. Swedo |
|
National
Institutes of Health |
Undergraduates Trainees (2000-2005) Currently
attending
| Brent
Bedke |
|
University
of Utah School of Medicine |
| Cody
Mickelsen |
|
University
of Vermont Medical School |
| Kent
Lofley |
|
Kirksville
College of Osteopathic Medicine |
| Douglas
Durrant |
|
Albany
Medical College Graduate School |
| Melanie
Fillmore |
|
University
of Utah School of Medicine |
| Randy
Johnson |
|
John
Hopkins University Graduate School |
| Corinna
Knorr |
|
Utah
State University Graduate School |
| James
Matthews |
|
Arizona
College of Osteopathic Medicine |
| Nathan
Adams |
|
University
of Pennsylvania, oral surgery |
| Jeremy
Franklin |
|
Penn.
State College of Osteopathic Medicine |
| Alma
Garcia |
|
Ohio
State University Osteopathic Medicine |
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